STAT3 antibody, PAb

Biorbyt

STAT3 antibody, PAb

10

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

100 ug/ml

Unconjugated

Rabbit

IgG

Rabbit polyclonal to STAT3. Signal transducer and activator of transcription 3 (STAT3) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. PIAS3 protein is a specific inhibitor of STAT3. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Human, Mouse

2°C to 8°C,-20°C

12352203