STAT3 (phospho Tyr705) antibody - Orthogonal Validated

Catalog number: GTX133464_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
GTX133464 WB Image
GTX133464 WB Image...

Product specifications for - STAT3 (phospho Tyr705) antibody - Orthogonal Validated

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Species: Human, Mouse
Host: Rabbit
Target: STAT3
Target description: signal transducer and activator of transcription 3
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Modification type: Phosphorylated
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.66 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
Gene ID: 6774
Swiss prot ID: P40763
Additional information: 
Synonyms: acute-phase response factor; ADMIO; ADMIO1; APRF; DNA-binding protein APRF; HIES; signal transducer and activator of transcription 3
"Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway." Shen M et al., 2019 Apr 8, J Exp Clin Cancer Res Read more
"Inhibition of miR-221 influences bladder cancer cell proliferation and apoptosis." Liu H et al., 2017 Jul, Eur Rev Med Pharmacol Sci Read more
"Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells." Li X et al., 2017 Dec, Biomed Pharmacother Read more