Overview
- SupplierGeneTex
- Product NameSTAT5A antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Gfi-1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells. Lee MC et al., 2014 Jan, J Leukoc BiolRead more
- Phosphorylation of calcium/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells. Chi M et al., 2016 Sep 8, Sci RepRead more