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GTX48659 ChIP assay Image
GTX48659 ChIP assay Image
GTX48659 ChIP assay Image

TAF1 antibody

Research Use Only
GTX48659
GeneTex
ApplicationsImmunoPrecipitation, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    TAF1 antibody
  • Delivery Days Customer
    10
  • Applications
    ImmunoPrecipitation, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.1 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex, which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors. TFIID nucleates the formation of transcription pre-initiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II. TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors. For example, TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue, leading to MDM2-mediated degradation of TP53. TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1). The retinoblastoma tumor suppressor protein, RB1, interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity. TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18% of mammalian genes.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Valproate-Induced Epigenetic Upregulation of Hypothalamic Fto Expression Potentially Linked with Weight Gain. Zhang H et al., 2021 Aug, Cell Mol Neurobiol
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