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GTX124207 IHC-P Image
GTX124207 IHC-P Image
GTX124207 IHC-P Image

TET1 antibody [N3C1] - KO/KD, Orthogonal, Overexpression Validated

Research Use Only
GTX124207
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    TET1 antibody [N3C1] - KO/KD, Orthogonal, Overexpression Validated
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.05 mg/ml
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
  • Reactivity
    Human, Monkey, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. Cleven AHG et al., 2017, Clin Sarcoma Res
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  • 5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma. Barazeghi E et al., 2016, Clin Epigenetics
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  • 5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme. Ciccarone F et al., 2015 Sep 15, Oncotarget
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  • A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR et al., 2017 Aug 21, Nucleic Acids Res
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  • A Positive Feedback Loop of TET3 and TGF-beta1 Promotes Liver Fibrosis. Xu Y et al., 2020 Feb 4, Cell Rep
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  • Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. Ichimura N et al., 2015 Aug, Cancer Prev Res (Phila)
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  • Abnormal activity of transcription factors gli in high-grade gliomas. Volnitskiy A et al., 2019, PLoS One
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  • Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells. Grosser C et al., 2015, Epigenetics
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  • Association of TET1 expression with colorectal cancer progression. Tian Y et al., 2017 Mar, Scand J Gastroenterol
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  • Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Weber AR et al., 2016 Mar 2, Nat Commun
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