GTX124207 IHC-P Image
TET1 antibody [N3C1] - KO/KD, Orthogonal, Overexpression Validated
GTX124207
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey, Mouse
Overview
- SupplierGeneTex
- Product NameTET1 antibody [N3C1] - KO/KD, Orthogonal, Overexpression Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1.05 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionDioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
- ReactivityHuman, Monkey, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. Cleven AHG et al., 2017, Clin Sarcoma ResRead more
- 5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma. Barazeghi E et al., 2016, Clin EpigeneticsRead more
- 5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme. Ciccarone F et al., 2015 Sep 15, OncotargetRead more
- A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Good CR et al., 2017 Aug 21, Nucleic Acids ResRead more
- A Positive Feedback Loop of TET3 and TGF-beta1 Promotes Liver Fibrosis. Xu Y et al., 2020 Feb 4, Cell RepRead more
- Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. Ichimura N et al., 2015 Aug, Cancer Prev Res (Phila)Read more
- Abnormal activity of transcription factors gli in high-grade gliomas. Volnitskiy A et al., 2019, PLoS OneRead more
- Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells. Grosser C et al., 2015, EpigeneticsRead more
- Association of TET1 expression with colorectal cancer progression. Tian Y et al., 2017 Mar, Scand J GastroenterolRead more
- Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Weber AR et al., 2016 Mar 2, Nat CommunRead more