Overview
- SupplierGeneTex
- Product NameTGF beta 2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration2.66 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Human placenta-derived mesenchymal stem cells ameliorate orbital adipogenesis in female mice models of Graves ophthalmopathy. Park M et al., 2019 Aug 9, Stem Cell Res TherRead more
- PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves ophthalmopathy through SREBP2/HMGCR pathway. Park M et al., 2021 May 29, Stem Cell Res TherRead more