Bio-Connect

Thymidylate Synthase Antibody Cocktail

Research Use Only
ORB385751
Biorbyt
ApplicationsImmunoHistoChemistry
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    Thymidylate Synthase Antibody Cocktail
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
  • Certification
    Research Use Only
  • Clone ID
    TS106 + TMS715
  • Isotype
    IgG
  • Scientific Description
    It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
  • UNSPSC
    12352203