GTX11227 FACS Image
TLR4 antibody [HTA125] (PE)
GTX11227
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
ReactivityCanine, Guinea Pig, Human, Porcine, Primate
Overview
- SupplierGeneTex
- Product NameTLR4 antibody [HTA125] (PE)
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHTA125
- ConjugateRPE
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ReactivityCanine, Guinea Pig, Human, Porcine, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Brutons tyrosine kinase mediates FcgammaRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils. Krupa A et al., 2013 Feb, Am J Respir Cell Mol BiolRead more