GTX75737 FACS Image
TLR4 antibody [HTA125]
GTX75737
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityCanine, Feline, Guinea Pig, Human, Porcine, Primate
Overview
- SupplierGeneTex
- Product NameTLR4 antibody [HTA125]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHTA125
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ReactivityCanine, Feline, Guinea Pig, Human, Porcine, Primate
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Brutons tyrosine kinase mediates FcgammaRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils. Krupa A et al., 2013 Feb, Am J Respir Cell Mol BiolRead more
- Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Tzeng HP et al., 2008 Mar, Am J Physiol Heart Circ PhysiolRead more
- Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. Henning LN et al., 2008 Jun 15, J ImmunolRead more