GTX75742 FACS Image
GTX75742 FACS Image
TLR4 antibody [HTA125]
GTX75742
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Product group Antibodies
ReactivityCanine, Feline, Guinea Pig, Human, Mouse, Porcine, Primate
Overview
- SupplierGeneTex
- Product NameTLR4 antibody [HTA125]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHTA125
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ReactivityCanine, Feline, Guinea Pig, Human, Mouse, Porcine, Primate
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- 3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways. Chao W et al., 2017 Sep, Int ImmunopharmacolRead more
- 6-Bromoindirubin-3-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-kappaB and TLR4/MAPK Signaling Pathways. Liu C et al., 2019 Dec, InflammationRead more
- Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-gamma in THP-1-derived macrophages. Hu K et al., 2013 Dec 5, Eur J PharmacolRead more
- Anti-inflammatory effects of triptolide in LPS-induced acute lung injury in mice. Wei D et al., 2014 Aug, InflammationRead more
- Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy. Huang CY et al., 2020 Jun 10, NutrientsRead more
- Brutons tyrosine kinase mediates FcgammaRIIa/Toll-like receptor-4 receptor crosstalk in human neutrophils. Krupa A et al., 2013 Feb, Am J Respir Cell Mol BiolRead more
- Cryptotanshinone inhibits prostaglandin E2 production and COX-2 expression via suppression of TLR4/NF-kappaB signaling pathway in LPS-stimulated Caco-2 cells. Cao SG et al., 2018 Mar, Microb PathogRead more
- Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs. Weng J et al., 2021, TheranosticsRead more
- Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-kappaB and MAPKs signaling pathways. Fu Y et al., 2013 Jan 9, J EthnopharmacolRead more
- Mycobacterium tuberculosis Upregulates TNF-alpha Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial Cells. Chen WL et al., 2015, PLoS OneRead more