Overview
- SupplierGeneTex
- Product NameTLR9 antibody [N1N2], N-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.71 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Basophils activated via TLR signaling may contribute to pathophysiology of type 1 autoimmune pancreatitis. Yanagawa M et al., 2018 Mar, J GastroenterolRead more
- Campylobacter jejuni disrupts protective Toll-like receptor 9 signaling in colonic epithelial cells and increases the severity of dextran sulfate sodium-induced colitis in mice. OHara JR et al., 2012 Apr, Infect ImmunRead more