TNFRSF14 antibody [Laury-1]
GTX16093
ApplicationsFlow Cytometry, ImmunoPrecipitation
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameTNFRSF14 antibody [Laury-1]
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ImmunoPrecipitation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDLaury-1
- HostRat
- IsotypeIgG
- Scientific DescriptionTNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is an acronym, which stands for is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes . The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203