GTX102640 IHC-P Image
Topoisomerase II beta antibody [C3], C-term
GTX102640
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameTopoisomerase II beta antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.48 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2. Hangas A et al., 2018 Oct 12, Nucleic Acids ResRead more
- In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells. Chen JC et al., 2019 Sep 9, BiomoleculesRead more
- Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining. Liu TP et al., 2018 Nov, R Soc Open SciRead more