Overview
- SupplierGeneTex
- Product NametPA antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.15 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. Svalina MN et al., 2016 Jun 3, Sci RepRead more