GTX113029 ICC/IF Image
TRAF6 antibody [N2C2], Internal
GTX113029
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameTRAF6 antibody [N2C2], Internal
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.3 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells. Nara K et al., 2019 Nov, J Cell PhysiolRead more
- Antiosteoclastogenic activity of silicate-based materials antagonizing receptor activator for nuclear factor kappaB ligand-induced osteoclast differentiation of murine marcophages. Hung CJ et al., 2013 Dec, J EndodRead more
- Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA. Huang WC et al., 2019 Jan 18, ChembiochemRead more
- Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling. Lim TJF et al., 2020 Aug 3, J Exp MedRead more
- The MicroRNAs in the Pathogenesis of Metabolic Memory. Zhong X et al., 2015 Sep, EndocrinologyRead more