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GTX113029 ICC/IF Image
GTX113029 ICC/IF Image
GTX113029 ICC/IF Image

TRAF6 antibody [N2C2], Internal

Research Use Only
GTX113029
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    TRAF6 antibody [N2C2], Internal
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.3 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells. Nara K et al., 2019 Nov, J Cell Physiol
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  • Antiosteoclastogenic activity of silicate-based materials antagonizing receptor activator for nuclear factor kappaB ligand-induced osteoclast differentiation of murine marcophages. Hung CJ et al., 2013 Dec, J Endod
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  • Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA. Huang WC et al., 2019 Jan 18, Chembiochem
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  • Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling. Lim TJF et al., 2020 Aug 3, J Exp Med
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  • The MicroRNAs in the Pathogenesis of Metabolic Memory. Zhong X et al., 2015 Sep, Endocrinology
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