Overview
- SupplierGeneTex
- Product NameTropomyosin 1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.05 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A study of the spatial protein organization of the postsynaptic density isolated from porcine cerebral cortex and cerebellum. Yun-Hong Y et al., 2011 Oct, Mol Cell ProteomicsRead more
- Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential. Oldershaw R et al., 2019 May 1, Stem Cells DevRead more
- Proteomic analysis of rhein-induced cyt: ER stress mediates cell death in breast cancer cells. Huang HJ et al., 2014 Dec, Mol BiosystRead more