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Troponin I skeletal muscle antibody [12F10]

Research Use Only
GTX28293
GeneTex
ApplicationsWestern Blot, ELISA, Purification/Extraction/Isolation
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Troponin I skeletal muscle antibody [12F10]
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ELISA, Purification/Extraction/Isolation
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    12F10
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203