TRP1 / Tyrosinase-Related Protein-1 Antibody

Biorbyt

TRP1 / Tyrosinase-Related Protein-1 Antibody

16

Flow Cytometry

Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Immunohistochemistry (Frozen): 1-2ug/ml for 30 min at RT FACS, IF, IHC-Fr

Research Use Only

TA99

IgG

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

12352203