TSC2 antibody, PAb

Biorbyt

TSC2 antibody, PAb

16

Western Blot

WB:1:500-1:1000 WB

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Rabbit polyclonal to TSC2.Tuberin (TSC2) forms a complex with TSC1 and inhibits the nutrient-mediated or growth factorstimulatedphosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling.TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of theprotein kinase activity of mTORC1. It is implicated as a tumor suppressor. TSC2 is involved inmicrotubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Defects in TSC2 causetuberous sclerosis type 2 (TSC2) and lymphangioleiomyomatosis (LAM).

Human, Mouse

2°C to 8°C,-20°C

12352203