Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)
ORB386164
Overview
- SupplierBiorbyt
- Product NameThyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)
- Delivery Days Customer16
- ApplicationsImmunoHistoChemistry
- Applications SupplierImmunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
- CertificationResearch Use Only
- Clone IDSPM222
- IsotypeIgG
- Scientific DescriptionThyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
- UNSPSC12352203