UBC antibody

Biorbyt

UBC antibody

16

WB: 1:1000-2000, IHC-P: 1:50-100 IHC-P, WB

Research Use Only

IgG

Rabbit polyclonal antibody to UBC. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target proteinubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the ubiquitinactivating enzyme (UBE1 or E1). The activated ubiquitin is subsequently transferred to the ubiquitincarrier protein E2, and then from E2 to ubiquitin ligase E3 for final delivery to the amino group of the target protein lysine residue (13). Combinatorial interactions of different E2 and E3 proteins result in substrate specificity (4). UBE1 has two isofoms: UBE1a is a nuclear protein of 117 kDa while UBE1b is a nuclear and cytoplasmic protein of 110 kDa

-20°C

12352203