Ubiquitin Antibody
ORB534192
Overview
- SupplierBiorbyt
- Product NameUbiquitin Antibody
- Delivery Days Customer16
- ApplicationsImmunoHistoChemistry
- Applications SupplierWestern blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P, WB
- CertificationResearch Use Only
- Clone IDPBQN-1
- IsotypeIgG
- Scientific DescriptionUbiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms. The addition of ubiquitin to a substrate protein is called ubiquitination or less frequently ubiquitylation. Ubiquitination affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin to lysine residues on the protein substrate via an isopeptide bond, cysteine residues through a thioester bond, serine and threonine residues through an ester bond, or the amino group of the proteins N-terminus via a peptide bond. [Wiki]
- UNSPSC12352203