Overview
- SupplierGeneTex
- Product NameUCP2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration3.08 mg/ml
- IsotypeIgG
- Scientific DescriptionMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5-UCP3-UCP2-3. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Betaine promotes lipid accumulation in adipogenic-differentiated skeletal muscle cells through ERK/PPARgamma signalling pathway. Wu W et al., 2018 Oct, Mol Cell BiochemRead more
- Muscle-specific deletion of Prkaa1 enhances skeletal muscle lipid accumulation in mice fed a high-fat diet. Wu W et al., 2018 May, J Physiol BiochemRead more
- Validation of Antiobesity Effects of Black Soybean Seed Coat Powder Suitable as a Food Material: Comparisons with Conventional Yellow Soybean Seed Coat Powder. Moriyasu Y et al., 2021 Apr 13, FoodsRead more