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GTX113963 ICC/IF Image
GTX113963 ICC/IF Image
GTX113963 ICC/IF Image

UHRF1 antibody

Research Use Only
GTX113963
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
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Overview

  • Supplier
    GeneTex
  • Product Name
    UHRF1 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.97 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • A proteomic characterization of factors enriched at nascent DNA molecules. Lopez-Contreras AJ et al., 2013 Apr 25, Cell Rep
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  • H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation. Kim KB et al., 2015 Apr 20, Nucleic Acids Res
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  • Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline. Fan X et al., 2021 Sep, PLoS Genet
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  • UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications. Gao Y et al., 2021 Nov 1, Cancer Lett
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