USP5 antibody [2F5] - Overexpression Validated

GeneTex

USP5 antibody [2F5] - Overexpression Validated

10

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2F5

1 mg/ml

Mouse

IgG

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored Lys-48-linked polyubiquitin disassembly. Binds linear and Lys-63-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition.

Canine, Human, Monkey, Mouse, Rat

2°C to 8°C,-20°C

12352203