USP5 antibody [2H5] - Overexpression Validated

GeneTex

USP5 antibody [2H5] - Overexpression Validated

10

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2H5

0.99 mg/ml

Mouse

IgG

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored Lys-48-linked polyubiquitin disassembly. Binds linear and Lys-63-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition.

Canine, Human, Monkey, Rat

2°C to 8°C,-20°C

12352203