Catalog number: HY-P9911_1mg
Brand: MedChem Express
Packing: 1 mg
Other sizes: 5 mg
Price: € 366.00
Expected delivery time: 10 days

Product specifications for - Vedolizumab

Product group: Antibodies
Category: Primary Antibodies
Molecular weight: 146814.90
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Scientific information: 
Scientific info: Vedolizumab is a humanized monoclonal antibody that targets the alpha4beta7 integrin for the treatment of ulcerative colitis and Crohn's disease. IC50 & Target: Integrin[1] In Vitro: Vedolizumab does not bind to the majority of memory CD4+ T lymphocytes (60%), neutrophils, and most monocytes. The highest level of vedolizumab binding is to a subset (25%) of human peripheral blood memory CD4+ T lymphocytes that include gut-homing interleukin 17 T-helper lymphocytes. Vedolizumab also binds to eosinophils at high levels, and to naive T-helper lymphocytes, naive and memory cytotoxic T lymphocytes, B lymphocytes, natural killer cells, and basophils at lower levels, vedolizumab binds to memory CD4+ T and B lymphocytes with subnanomolar potency (EC50=0.3-0.4 nM). Vedolizumab selectively inhibits adhesion of alpha4beta7-expressing cells to mucosal addressin cell adhesion molecule 1 (IC50=0.02-0.06 g/mL) and fibronectin (IC50=0.02 g/mL), but not vascular cell adhesion molecule 1[1]. In Vivo: Blockade of alpha4beta7 receptors on T-lymphocytes has been shown to occur for several weeks after a single dose of vedolizumab. The drug concentration following the infusion has been shown to be dose related with a mean maximum concentration of 12.5 ug/mL in those receiving 0.5 mg/kg of vedolizumab and 52.0 ug/mL in those receiving 2 mg/kg. The serum half-life of these two doses is 9-12 days respectively and saturation of alpha4beta7 receptors on T-lymphocytes is >90% at both 4-6 weeks following infusion. In a dose ranging study, the serum drug concentrations increase with increasing dose and when regular induction infusions are used (on day 1, 15, 29 and 85), the serum half-life is between 15 and 22 days across all groups[1].
Safety information: 
Additional information: 
Synonyms: HY-P9911; MedChem Express