Overview
- SupplierGeneTex
- Product NameVEGF antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.17 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- [The vascular endothelial growth factor in patients with advanced ovarian cancer on the background of chemotherapy according to the AP scheme.] Abakumova TV et al., 2018, Klin Lab DiagnRead more
- Acute and chronic hemorrhage from radiation-induced cavernous malformation associated with late-delayed radiation necrosis in long surviving glioma patients: A case report. Oishi T et al., 2020 Jan, Oncol LettRead more
- Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction. Hung TH et al., 2021 Nov, Brain PatholRead more
- Beneficial effects of atorvastatin on sex-specific cognitive impairment induced by a cerebral microhaemorrhage in mice. Bergeron S et al., 2021 Apr, Br J PharmacolRead more
- Brain-derived neurotrophic factor (BDNF) -TrKB signaling modulates cancer-endothelial cells interaction and affects the outcomes of triple negative breast cancer. Tsai YF et al., 2017, PLoS OneRead more
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells. Lee PC et al., 2019, PLoS OneRead more
- Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative. Kumarasamy VM et al., 2017 Jul, Int J OncolRead more
- Dickkopf-related protein 1 induces angiogenesis by upregulating vascular endothelial growth factor in the synovial fibroblasts of patients with temporomandibular joint disorders. Jiang SJ et al., 2015 Oct, Mol Med RepRead more
- Differential Expression of CD3, TNF-alpha, and VEGF Induced by Olanzapine on the Spleen of Adult Male Albino Rats and the Possible Protective Role of Vitamin C. Youssef S et al., 2019 May 23, BiomedicinesRead more
- Effects of Chinese medicinal herbs on expression of brain-derived Neurotrophic factor (BDNF) and its interaction with human breast cancer MDA-MB-231 cells and endothelial HUVECs. Chiu JH et al., 2017 Aug 12, BMC Complement Altern MedRead more