VEGF Receptor 2 antibody
GTX17530
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameVEGF Receptor 2 antibody
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- HostChicken
- IsotypeIgY
- Scientific DescriptionVEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.
- ReactivityBovine, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Acute venous occlusion enhances matrix metalloprotease activity: Implications on endothelial dysfunction. Alsaigh T et al., 2011 Jan, Microvasc ResRead more
- Allyl isothiocyanate ameliorates angiogenesis and inflammation in dextran sulfate sodium-induced acute colitis. Davaatseren M et al., 2014, PLoS OneRead more
- Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress. Altshuler AE et al., 2012 Mar, Cell Mol BioengRead more