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ProductsBack/TNFSF15 Antibody / VEGI / TL1A

TNFSF15 Antibody / VEGI / TL1A

Research Use Only
ORB386086
Biorbyt
ApplicationsImmunoHistoChemistry
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Biorbyt
  • Product Name
    TNFSF15 Antibody / VEGI / TL1A
  • Delivery Days Customer
    16
  • Applications
    ImmunoHistoChemistry
  • Applications Supplier
    Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P
  • Certification
    Research Use Only
  • Clone ID
    VEGI/1283
  • Isotype
    IgG
  • Scientific Description
    TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.
  • UNSPSC
    12352203