WDR83 antibody, PAb
ORB18050
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
Overview
- SupplierBiorbyt
- Product NameWDR83 antibody, PAb
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoHistoChemistry
- Applications SupplierWestern blot - 0.1-0.5 μg/ml - Human, Rat - Mouse - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human, Rat - Mouse - By Heat WB, IHC
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration500 ug/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit Polyclonal to WDR83. MORG1 (mitogen-activated protein kinase organizer 1), a member of the WD-40 protein family that was isolated as a binding partner of the extracellular signal-regulated kinase (ERK) pathway scaffold protein MP1. MORG1 specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex. MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. Suppression of MORG1 by short interfering RNA leads to a marked reduction in ERK activity when cells are stimulated with serum. MORG1 is a component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.
- ReactivityChicken, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203