Overview
- SupplierGeneTex
- Product NameWnt1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.01 mg/ml
- IsotypeIgG
- Scientific DescriptionThe WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Najdi R et al., 2012 Sep, DifferentiationRead more
- Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCdelta- and Wnt-1/beta-catenin-mediated pathways. Lii CK et al., 2016 May 3, OncotargetRead more
- Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway. Chen J et al., 2018 Feb 15, Stem Cells DevRead more
- Wnt proteins synergize to activate beta-catenin signaling. Alok A et al., 2017 May 1, J Cell SciRead more