Clusterin Human ELISA

Catalog number: RD194034200R
Brand: BioVendor
Packing: 96 wells
Price: € 510.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Clusterin Human ELISA

Overview: 
Product group: Assays
Category: ELISA / EIA
Properties: 
Molecular weight: 75 - 80 kDa
Assay Sensitivity: 0,5 ng/ml
Assay Precision: Inter assay: n = 8, CV = 7,8%, Intra assay: n = 8, CV = 6,2%,
Assay Sample Type: serum, plasma, cerebrospinal fluid (CSF), urine, cell culture, and cell lysate
Assay Time: The total assay time is less than 3.5 hours.
Assay Detection Range: 5 - 160 ng/ml
  Research Use Only
UNSPSC: 41116158
Storage instructions: Store the complete kit at 2-8-¦C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Scientific information: 
Scientific info: Clusterin (Apolippoprotein J, SP-40,40, TRPM-2, SGP-2, pADHC-9, CLJ, T64, GP III, XIP8) is a highly conserved disulfide-linked secreted heterodimeric glycoprotein of 75-80 kDa but truncated forms targeted to the nucleus have also been identified. The protein is constitutively secreted by a number of cell types including epithelial and neuronal cells and is a major protein in physiological fluids including plasma, milk, urine, cerebrospinal fluid and semen. Due to its wide breath of tissue distribution many diverse physiological functions have been attributed to Clusterin including sperm maturation, membrane recycling, lipid transportation, tissue remodelling, complement inhibition and cell-cell or cell-substratum interactions. Moreover, it was proposed that Clusterin functions as an extracellular chaperon that stabilizes stressed proteins in a folding-competent state, and that the protein is involved in programmed cell death. Another defining prominent function of Clusterin is its induction in many severe physiological disturbances states including kidney degenerative diseases, prostate and vesicle carcinogenesis, ovarian cancer and several neurodegenerative conditions (Alzheimer s disease). Recent study demonstrates, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. These data raise the possibility that elevated Clusterin levels in serum may represent a strong indication of vascular damage. In patients with systemic lupus erythematosus (SLE), reduced serum Clusterin levels correlated inversely with disease activity. Lowered Clusterin levels could be involved in the pathogeneses of SLE on account of decreased protective effects. Another interesting observation obtained in rat model suggests that measurement of urinary Clusterin levels may be a useful clinical marker for the severity of renal tubular damage. Furthermore, urinary Clusterin may also help to differentiate between tubular and glomerular forms of proteinuria. Areas of investigation: Coronary heart diseases, Myocardial infarction, Neurodegenerative diseases, Kidney degenerative disease, Renal tubular damage
Additional information: 
Synonyms: RD194034200R; BioVendor
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