IL-1alpha (mouse) Matched Pair Detection Set

Catalog number: AG-46B-0004-KI01
Brand: AdipoGen Life Sciences
Packing: 1 set
Price: € 560.00
Expected delivery time: 7 days
Quantity:

Product specifications for - IL-1alpha (mouse) Matched Pair Detection Set

Overview: 
Product group: Assays
Category: ELISA / EIA
Application: ELISA
Species: Mouse
Target: Il1a
Target description: interleukin 1 alpha
Properties: 
Assay Sensitivity: 10pg/ml
Assay Detection Range: 15.6 to 2000pg/ml
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Storage instructions: -20°C
Scientific information: 
Scientific info: Matched Pair Detection Set. Detects mouse IL-1alpha. Does not detect human IL-1alpha or mouse IL-1beta. Colorimetric assay. Sample Type: Cell Culture Supernatant. Range: 15.6 to 2000pg/ml. Sensitivity: 10pg/ml. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner. - The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Gene ID: 16175
Swiss prot ID: P01582
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: IL-1 alpha; Il-1a; interleukin-1 alpha