Leptin Human ELISA, Clinical Range

Catalog number: RD191001100
Brand: BioVendor
Packing: 96 wells
Price: € 326.00
Expected delivery time: 7 days

Product specifications for - Leptin Human ELISA, Clinical Range

Product group: Assays
Category: ELISA / EIA
Molecular weight: 16 kDa
Assay Sensitivity: 0,2 ng/ml
Assay Precision: Inter assay: n=6, CV = 5,6%, Intra assay: n=8, CV = 5,9%,
Assay Time: The total assay time is less than 2.5 hours
Assay Detection Range: 1 - 50 ng/ml
  IVD Certification
UNSPSC: 41116158
Storage instructions: Store the kit at 2-8-¦C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Scientific information: 
Scientific info: Leptin, the product of the ob (obese) gene, is a single-chain 16 kDa protein consisting of 146 amino acid residues. Leptin is produced mainly in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and body weight regulation. It targets the central nervous system, particularly hypothalamus, affecting food intake. The primary effect of leptin appears to be mediated by leptin receptors expressed mainly in the hypothalamus. In humans, leptin levels correlate with body mass index (BMI) and percentage body fat, and are elevated even in obese individuals. Leptin has a dual action, it decreases the appetite and increases energy consumption, causing more fat to be burned. Leptin is secreted in circadian fashion with nocturnal rise in both lean and obese patients. Mutations of the ob gene resulting in leptin deficiency are the cause of obesity in the ob/ob mice. Endogeneous leptin can normalize their body weight. In contrast, high levels of leptin in obese human subjects point to an insensitivity to endogeneous leptin. Other factors in addition to the amount of body fat appear to regulate leptin action: insulin, glucocorticoids, catecholamines and sex hormones. Studies have shown that leptin may be linked to reproductive function.
Additional information: 
Synonyms: RD191001100; BioVendor
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