PD-L1 (human) ELISA Kit

Catalog number: AG-45B-0016-KI01
Brand: AdipoGen Life Sciences
Packing: 1 x 96 well plate
Other sizes: Other sizes available, please contact us.
Price: € 550.00
Expected delivery time: 7 days
Quantity:
Figure: Specific quantitation of AP...

Product specifications for - PD-L1 (human) ELISA Kit

Overview: 
Product group: Assays
Category: ELISA / EIA
Application: ELISA
Species: Human
Target: CD274
Target description: CD274 molecule
Properties: 
Assay Sensitivity: 0.8pg/ml
Assay Detection Range: 2.34 to 150pg/ml
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Scientific information: 
Scientific info: ELISA Assay. Detects soluble human PD-L1 (sPD-L1) in serum, plasma and cell culture supernatant. Assay Type: Sandwich. Sample Type: Cell Culture Supernatant,Plasma,Serum. Range: 2.34 to 150pg/ml. Sensitivity: 0.8pg/ml. PD-L1 (also known as Programmed Cell Death 1 Ligand Protein 1; CD274 or B7-H1) is an immuno-coinhibitory member of the B7 family and functions as an immune checkpoint via its interaction with its receptors PD-1 (CD279) and CD80 (also known as B7-1). PD-L1 is expressed by hematopoietic cells such as T, B and dendritic cells and by parenchymal cells in response to cytokine (i.e. IFN-gamma) induction. Ligation of PD-1 by PD-L1 (B7-H1; CD274) or PD-L2 (B7-DC; CD273) inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma and also inhibits BCR mediated signaling. PD-L1 binding to CD80 inhibits T cells proliferation. PD-1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Soluble form of PD-L1 (sPD-L1) is expressed upon immune cells activation and can be secreted in the serum/plasma. Soluble checkpoints, such as sPD-1 or sPD-L1, are involved in positive or negative immune regulation and changes in their serum/plasma levels affect the development, prognosis and treatment of cancer. Increase of sPD-L1 or sPD-1 levels have been detected in patients with different types of cancer. This PD-L1 (human) ELISA kit is developed to detect specifically sPD-L1 (human) in different biological fluids. - PD-L1 (also known as Programmed Cell Death 1 Ligand Protein 1; CD274 or B7-H1) is an immuno-coinhibitory member of the B7 family and functions as an immune checkpoint via its interaction with its receptors PD-1 (CD279) and CD80 (also known as B7-1). PD-L1 is expressed by hematopoietic cells such as T, B and dendritic cells and by parenchymal cells in response to cytokine (i.e. IFN-gamma) induction. Ligation of PD-1 by PD-L1 (B7-H1; CD274) or PD-L2 (B7-DC; CD273) inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma and also inhibits BCR mediated signaling. PD-L1 binding to CD80 inhibits T cells proliferation. PD-1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Soluble form of PD-L1 (sPD-L1) is expressed upon immune cells activation and can be secreted in the serum/plasma. Soluble checkpoints, such as sPD-1 or sPD-L1, are involved in positive or negative immune regulation and changes in their serum/plasma levels affect the development, prognosis and treatment of cancer. Increase of sPD-L1 or sPD-1 levels have been detected in patients with different types of cancer. This PD-L1 (human) ELISA kit is developed to detect specifically sPD-L1 (human) in different biological fluids.
Gene ID: 29126
Swiss prot ID: Q9NZQ7
Additional information: 
Synonyms: B7 homolog 1; B7-H; B7H1; CD274 antigen; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1