Progranulin (human) ELISA Kit

Catalog number: AG-45A-0018YEK-KI01
Brand: AdipoGen Life Sciences
Packing: 96 wells
Price: € 565.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Progranulin (human) ELISA Kit

Overview: 
Product group: Assays
Category: ELISA / EIA
Application: ELISA
Species: Human
Target: GRN
Target description: granulin precursor
Properties: 
Assay Sensitivity: 32pg/ml
Assay Detection Range: 0.063 to 4ng/ml
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41116158
Storage instructions: 2-¦C to 8-¦C
Scientific information: 
Scientific info: ELISA Assay. Detects human progranulin. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum, Urine. Range: 0.063 to 4ng/ml. Sensitivity: 32pg/ml. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimers disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. - Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. New cutting-edge publications have shown that progranulin might be a biomarker not only for FTLD, but also for other types of Alzheimers disease (AD). This new data even supposes the potential of progranulin to be a biomarker for MCI (Mild Cognitive Impairment), which would be a hallmark in AD research. Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Gene ID: 2896
Swiss prot ID: P28799
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-45A-0018YEK-KI01; AdipoGen Life Sciences; acrogranin; CLN11; GEP; GP88; granulin-epithelin; granulins; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; progranulin
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration: R. Ghidoni, et al.; Neurology 71, 1235 (2008) Read more
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia: R. Rademakers, et al.; Hum. Mol. Genet. 17, 3631 (2008) Read more
Serum progranulin concentrations may be associated with macrophage Infiltration into omental adipose tissue: B.S. Youn, et al.; Diabetes 58, 627 (2009) Read more
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members: N. Finch, et al.; Brain 132, 583 (2009) Read more
Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease: M. Carecchio, et al.; J. Neurol. Sci. 287, 291 (2009) Read more
Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes: M. De Riz, et al.; Neurosci. Lett. 469, 234 (2010) Read more
Low Serum Progranulin Predicts the Presence of Mutations: A Prospective Study: E.C. Schofield, et al.; J. Alzheimers Dis. 22, 981 (2010) Read more
A Novel Progranulin Mutation Causing Frontotemporal Lobar Degeneration with Heterogeneous Phenotypic Expression: G. Rossi, et al.; J. Alzheimers Dis. 23, 7 (2010) Read more
Pathogenic cysteine mutations affect progranulin function and production of mature granulins: J. Wang, et al.; J. Neurochem. 112, 1305 (2010) Read more
Microglial upregulation of progranulin as a marker of motor neuron degeneration: T. Philips, et al.; J. Neuropathol. Exp. Neurol. 69, 1191 (2010) Read more