Zinc-Alpha-2-Glycoprotein Human ELISA

Catalog number: RD191093100R
Brand: BioVendor
Packing: 96 wells
Price: € 613.00
Expected delivery time: 7 days
Quantity:

Product specifications for - Zinc-Alpha-2-Glycoprotein Human ELISA

Overview: 
Product group: Assays
Category: ELISA / EIA
Properties: 
Molecular weight: 41 kDa
Assay Precision: Inter assay: n = 4, CV = 6,6%, Intra assay: n = 8, CV = 3,9%,
Assay Sample Type: serum and plasma (EDTA, citrate, heparin)
Assay Time: The total assay time is less than 3 hours
Assay Detection Range: 3 - 100 ng/ml
  Research Use Only
UNSPSC: 41116158
Storage instructions: Store the kit at 2-8-¦C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Scientific information: 
Scientific info: Zinc-alpha-2-glycoprotein (ZAG, ZA2G, Azgp1, ZNGP1, Lipid-Mobilizing Factor, LMF) is a soluble 41 kDa glycoprotein belonging to the immunoglobuline protein family and consisting of a single polypeptide chain. Human ZAG shares 59% sequence identity with the murine homolog. ZAG is closely related to antigens of the class1 major histocompatibility complex (MHC I) and shares 30-40 % sequence identity with the heavy chain of MHC I. Most MHC-I members heterodimerize with beta-2-microglobuline (b2m) and bind peptides derived from intracellular proteins to present them to cytotoxic T cells. In contrast, ZAG is a soluble protein rather than being anchored to plasma membranes that acts independently on b2m and binds the hydrophobic ligand which may relate to its function in lipid metabolism. ZAG is widespread in body fluids and is also found in various human tissues such as adipose tissue, prostate, breast, skin, salivary gland, trachea, broncheus, lung, gastrointestinal tract, pancreas, liver and kidney. ZAG acts as a lipid mobilizing factor to induce lipolysis in adipocytes and plays an important role in lipid utilization and loss of adipose tissue, especially during cachexia, which occurs in patient suffering from cancer, AIDS and other chronic illnesses. The role of ZAG in cancer cachexia is also connected with its ability to directly influence expression of uncoupling proteins (UCPs) which are implicated in the regulation of energy balance. In human adipocytes, ZAG expression is regulated particularly through TNF-alpha and the PPAR gamma nuclear receptor. ZAG expression is also upregulated by glucocorticoides and attenuated by eicosapentaenoic acid (EPA) and beta-3-adrenoreceptor antagonists. ZAG is overexpressed in certain human malignant tumors such as prostate, breast, lung or bladder cancer and can relate to tumor differentiation. Additionally, ZAG plays a role in obesity, diabetic kidney disorders, frontotemporal dementia and regulation of melanin production by melanocytes. ZAG is proposed to have a therapeutic use in obesity and cachexia. It can be used as a marker for clinical analysis of diabetic nephropathy and as a marker for certain tumors.
Additional information: 
Synonyms: RD191093100R; BioVendor
Aregger F, Pilop C, Uehlinger DE, Brunisholz R, Carrel TP, Frey FJ, Frey BM. Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury. J Thorac Cardiovasc Surg. 2010 Mar,139 (3):692-700 Read more
Brettschneider J, Mogel H, Lehmensiek V, Ahlert T, Sussmuth S, Ludolph AC, Tumani H. Proteome Analysis of Cerebrospinal Fluid in Amyotrophic Lateral Sclerosis (ALS). Neurochem Res. 2008 May 15, Read more
Ceperuelo-Mallafre V, Escote X, Vilades C, Peraire J, Domingo P, Solano E, Sirvent JJ, Pastor R, Tinahones F, Leal M, Richart C, Vendrell J, Vidal F, Alba V, Aguilar A, Auguet T, Chacon MR, Lopez-Dupla M, Megia A, Miranda M, Olona M, Sauri A, Vargas M, Velasco I, Veloso S, Fontanet A, Gutierrez M, Mateo G, Munoz J, Sambeat MA. Zinc alpha-2 glycoprotein is implicated in dyslipidaemia in HIV-1-infected patients treated with antiretroviral drugs. HIV Med. 2012 May,13 (5):297-303 Read more
Ceperuelo-Mallafre V, Naf S, Escote X, Caubet E, Gomez JM, Miranda M, Chacon MR, Gonzalez-Clemente JM, Gallart L, Gutierrez C, Vendrell J. Circulating and adipose tissue gene expression of zinc-alpha2-glycoprotein in obesity: its relationship with adipokine and lipolytic gene markers in subcutaneous and visceral fat. J Clin Endocrinol Metab. 2009 Dec,94 (12):5062-9 Read more
Dichgans M, Petersen D. Angiographic complications in CADASIL. Lancet. 1997 Mar 15,349 (9054):776-7 Read more
Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009 Apr,150 (4):1688-96 Read more
Fain JN, Tagele BM, Cheema P, Madan AK, Tichansky DS. Release of 12 Adipokines by Adipose Tissue, Nonfat Cells, and Fat Cells From Obese Women. Obesity (Silver Spring). 2009 Oct 15, Read more
Felix K, Fakelman F, Hartmann D, Giese NA, Gaida MM, Schnolzer M, Flad T, Buchler MW, Werner J. Identification of serum proteins involved in pancreatic cancer cachexia. Life Sci. 2011 Jan 31,88 (5-6):218-25 Read more
Gao D, Trayhurn P, Bing C. Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes. Mol Cell Endocrinol. 2010 Aug 30,325 (1-2):135-42 Read more
Garrido-Sanchez L, Garcia-Fuentes E, Fernandez-Garcia D, Escote X, Alcaide J, Perez-Martinez P, Vendrell J, Tinahones FJ. Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. PLoS One. 2012,7 (3):e33264 Read more