Atlas Antibodies’ PrecisA™ neuroinflammation monoclonal antibodies

Atlas Antibodies offers a wide range of neuroinflammation markers. Their antibodies are affinity-purified, reproducible, and selective for their target proteins through an enhanced validation process. Discover how their antibodies can help you:

Neuroinflammation markers

Neuroinflammation broadly defines the collective reactive immune response in the brain and spinal cord in response to injury and disease.

Neuroinflammation has been implicated in acute brain trauma and hypoxic-ischemic brain damage following stroke, chronic infection and neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Lewy body dementia, and leukoencephalopathies like multiple sclerosis.

Atlas Antibodies offers a wide range of neuroinflammation markers targeting non-neuronal cell types involved in neuroinflammation processes such as microglia, oligodendrocytes, and astrocytes.

Microglia, astrocytes and oligodendrocytes in neuroinflammation

Glial cells, comprising astrocytes, oligodendrocytes, and microglia, are the non-neuronal cell population of the central nervous system (CNS). Glial cells do not produce electrical impulses. They maintain homeostasis, form myelin, and provide support and protection for neurons. Neuroinflammation arises within the CNS through phenotypic changes of the glial cells causing the release of different cytokines and chemokines, loss of myelin and neurons, recruitment, and infiltration of peripheral blood cells, mainly T-and B-cells, into the brain parenchyma.

Astrocyte markers

Astrocytes are the most abundant glial cell type in the CNS and the crucial regulators of innate and adaptive immune responses. Astrocytes regulate the formation, maturation, maintenance, and stability of synapses by secreting various molecules critical for synaptogenesis. Astrocytes also contribute to the induction and maintenance of the blood-brain barrier. In response to neuroinflammation, they undergo a process termed astrogliosis, which results in a spectrum of heterogenous changes that vary with etiology and severity of CNS injury. Classically, this process is characterized by upregulation of GFAP and vimentin, key astrocyte intermediate filaments, and hypertrophy of astrocyte processes. Antibodies targeting astrocytes include the Anti-GFAP, Anti-VIM, Anti-GLUL, Anti-S100B, Anti-EZR, and Anti-MT3.

ICC-IF of astrocytes and microglia in human brain tissue. Multiplexed immunofluorescence staining of human cerebral cortex showing microglia in green (Anti-TMEM119, AMAb91528) and astrocytes in red (Anti-MT3, HPA004011).

Microglia markers

Microglia cells are critical cellular mediators of neuroinflammatory processes. As the resident macrophage cells, they act as the first and main form of active immune defense in the CNS. Activation of microglia is a hallmark of brain pathology. The chronic activation of microglia may cause neuronal damage through the release of potentially cytotoxic molecules such as proinflammatory cytokines, reactive oxygen intermediates, proteinases, and complement proteins. For example, in the pathogenesis of Alzheimer´s disease, activated microglia participates in amyloid Aβ-plaques formation and the associated pathology. Antibodies targeting microglia cells include the Anti-AIF, Anti-CD68, Anti-HLA-DRA, Anti-ITGAM (CD11b), Anti-TMEM119, AIF1/Iba1-2, Anti-P2RY12, and Anti-PTPRC.

ICC-IF of activated microglia in AD. Immunofluorescence staining of human cerebral cortex from an Alzheimer’s disease patient (left) and a normal control (right) using the Anti-HLA-DRA antibody (AMAb91674) showing positivity in microglial cells (in green). Nuclei counterstained by DAPI, in blue.

Oligodendrocytes markers

Oligodendrocytes are highly specialized glial cells whose function is to myelinate the CNS axons (equivalent to the function performed by Schwann cells in the peripheral nervous system). Myelination of axons is fundamental for the rapid conduction of nerve impulses and contributes to axonal integrity. The devastating neurological deficits caused by demyelinating diseases, such as multiple sclerosis, clearly illustrate the importance of well-functioning oligodendrocytes. Antibodies targeting oligodendrocytes include the Anti-MBP, Anti-MOG, Anti-CNP, Anti-GRP17, and Anti-OlIg2.

IHC and ICC-IF of myelinated axons. Immunohistochemical staining of the human cerebral cortex (left) and the rat striatum (right) using the Anti-MOG antibody (AMAb91066) shows strong positivity in myelinated neural processes.

PrecisA monoclonals markers

Here you can find a selection of Atlas Antibodies’ PrecisA™ monoclonal antibodies targeting neuroinflammation processes.

Cat. No.DescriptionClone IDApplicationsClonalityHostVerified Species ReactivityIsotype
AMAb91634Anti-AGER AntibodyCL10587IHCMonoclonalMouseHuman, RatIgG2a
AMAb91635Anti-AGER AntibodyCL10591IHCMonoclonalMouseHuman, RatIgG1
AMAb91671Anti-AIF1 AntibodyCL10930IHCMonoclonalMouseHumanIgG2b
AMAb91672Anti-AIF1 AntibodyCL10936IHCMonoclonalMouseHumanIgG1
AMAb91677Anti-AMIGO3 AntibodyCL11023WBMonoclonalMouseHumanIgG1
AMAb91641Anti-ANO2 AntibodyCL10631IHCMonoclonalMouseHumanIgG1
AMAb91642Anti-ANO2 AntibodyCL10632IHCMonoclonalMouseHuman, RatIgG1
AMAb91646Anti-CD163 AntibodyCL10652IHC, WBMonoclonalMouseHuman, RatIgG1
AMAb91648Anti-CD163 AntibodyCL10658IHCMonoclonalMouseHumanIgG1
AMAb91661Anti-CRYAB AntibodyCL10758ICC-IF, IHC, WBMonoclonalMouseHuman, RatIgG1
AMAb91662Anti-CRYAB AntibodyCL10765IHC, WBMonoclonalMouseHumanIgG2b
AMAb91629Anti-CXCL13 AntibodyCL10543IHCMonoclonalMouseHumanIgG1
AMAb91667Anti-DYSF AntibodyCL10888IHC, WBMonoclonalMouseHumanIgG1
AMAb91664Anti-GAP43 AntibodyCL10847IHCMonoclonalMouseHumanIgG2b
AMAb91665Anti-GAP43 AntibodyCL10855IHCMonoclonalMouseHumanIgG1
AMAb91666Anti-GAP43 AntibodyCL10884IHCMonoclonalMouseHumanIgG2a
AMAb91624Anti-GPR17 AntibodyCL10474IHC, WBMonoclonalMouseHumanIgG1
AMAb91650Anti-GZMB AntibodyCL10662IHCMonoclonalMouseHumanIgG1
AMAb91673Anti-HLA-DRA AntibodyCL10961IHC, WBMonoclonalMouseHumanIgG1
AMAb91674Anti-HLA-DRA AntibodyCL10962IHC, WBMonoclonalMouseHumanIgG2a
AMAb91675Anti-HLA-DRA AntibodyCL10964IHC, WBMonoclonalMouseHumanIgG2b
AMAb91615Anti-IL17A AntibodyCL10252IHCMonoclonalMouseHumanIgG1
AMAb91617Anti-IL17RA AntibodyCL10283WBMonoclonalMouseHumanIgG2b
AMAb91619Anti-IL17RA AntibodyCL10309WBMonoclonalMouseHumanIgG1
AMAb91684Anti-IL7 AntibodyCL11132ICC-IFMonoclonalMouseHumanIgG1
AMAb91699Anti-ITGA4 AntibodyCL11294WBMonoclonalMouseHumanIgG2b
AMAb91636Anti-MS4A1 AntibodyCL10613IHC, WBMonoclonalMouseHumanIgG2a
AMAb91685Anti-OPALIN AntibodyCL11142IHCMonoclonalMouseHumanIgG1
AMAb91686Anti-OPALIN AntibodyCL11144IHCMonoclonalMouseHumanIgG2a
AMAb91639Anti-PLP1 AntibodyCL10622IHCMonoclonalMouseHuman, RatIgG1
AMAb91702Anti-RGMA AntibodyCL11342WBMonoclonalMouseHumanIgG2b
AMAb91689Anti-S100A8 AntibodyCL11171IHCMonoclonalMouseHumanIgG1
AMAb91690Anti-S100A9 AntibodyCL11191IHCMonoclonalMouseHumanIgG2a
AMAb91655Anti-SERPINA3 AntibodyCL10697IHCMonoclonalMouseHumanIgG1
AMAb91653Anti-SPP1 AntibodyCL10686IHCMonoclonalMouseHumanIgG1
AMAb91631Anti-TLR2 AntibodyCL10552WBMonoclonalMouseHumanIgG1
AMAb91693Anti-TRPM4 AntibodyCL11214ICC-IF, IHC, WBMonoclonalMouseHumanIgG1