Bromodomains

The bromodomain family contains an evolutionarily conserved protein fold that specifically binds acetylated lysine residues. This recognition facilitates function by promoting protein-protein interaction. Many bromodomain-containing proteins, such as Type A histone acetyltransferases, are chromatin remodeling enzymes. Other bromodomain-containing proteins act as transcription factors to regulate gene activity.

The human genome encodes more than 50 bromodomain-containing proteins, which can be subdivided into 8 families. These ‘readers’ of the histone code are important regulators of development and normal biological processes. Several key BRD-containing proteins include Brd2 and Brd3, which are associated with MHC recognition, inflammation, and immune response, and Brd4 (also called MCAP), which associates with chromosomes during mitosis. All three BRD proteins have been identified as potential cancer targets. Although a number of bromodomain inhibitors have been developed, including the widely used JQ1, their efficacy in disease states have been limited, highlighting the need for further development of bromodomain inhibitors.

BPS Bioscience has one of the largest libraries of bromodomian-containing proteins. Their portfolio includes highly purified proteins, assay kits, and inhibitors & activators. As with all of their products, they perform rigorous QC testing of their bromodomain products to ensure that they are producing only high-quality, consistent products.

References:

1.  Filippakopoulos, P., et al., Nat. Rev. Drug. Disc. 2014; 13: 337-356.

Assay Kits
ATAD2A
BRD2
BRPF3
TAF1L
ATAD2B
BRD3
CECR2
TRIM24
BAZ2B
BRD4
CREBBP

BRD
BRD9
SMARCA2

BRD1
BRDT
TAF1
 

Proteins
ASH1L
BRD3
FALZ
TAF1
ATAD2A
BRD4
GCN5
TAF1L
ATAD2B
BRD9
P300
TRIM24
BAZ1A
BRDT
PB1
TRIM28
BAZ1B
BRPF1
PCAF
WDR9
BAZ2B
BRPF3
PHIP
ZMYND11
BRD1
CECR2
SMARCA2
ZMYND8
BRD2
CREBBP
SMARCA4
 

Ligands
BET Bromodomain Ligand
Bromodomain Non-Acetylated Ligand 1
Bromodomain Ligand 2
Bromodomain Non-Acetylated Ligand 2
Bromodomain Ligand 3
Bromodomain Non-Acetylated Ligand 3
Bromodomain Ligand 4
Bromodomain Non-Acetylated Ligand 4

Inhibitors / Activators
(+)-JQ1
CHS-828
I-CBP112 (Hydrochloride)
RediSolution™ (+)-JQ1
(-)-JQ1
I-BET-762
OTX-015
RVX-208
Bromosporine
I-BET151 (GSK1210151A)
PFI-1
SGC-CBP30



Source:
Website: BPS Bioscience

Related to:
Brands: BPS Bioscience