hPDE10A-HEK293 Cell line

Catalog number: 60410
Brand: BPS Bioscience
Packing: 2 Vials
Price: € 9342.00
Expected delivery time: 7 days

Product specifications for - hPDE10A-HEK293 Cell line

Product group: Cell Culture
Category: Cell lines
Application note: Useful to monitor cAMP and PDE10A signaling pathway activity and to screen activators or inhibitors of PDE10A.
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352207
Form supplied: aqueous solution containing DMSO
Storage instructions: Store in liquid nitrogen immediately upon receipt.
Scientific information: 
Scientific info: Recombinant HEK293 cell line expressing human PDE10A2 (phosphodiesterase 10A, accession number NM_006661). N-terminal His-tagged human PDE10A2 has been stably expressed in a human embryonic kidney (HEK293) cell line. PDE10A2 expression was confirmed by Western blotting. The function of PDE10A2 was confirmed by cAMP detection assay. Forskolin is commonly used to raise levels of intracellular cyclic AMP (cAMP). When HEK293 cells are activated by forskolin, cAMP levels are upregulated in parental cells, whereas cells overexpressing PDE10A show reduction in cAMP accumulation. Inhibition of PDE10A activity restores cAMP levels.
Swiss prot ID: Q9Y233
Additional information: 
Synonyms: 60410; BPS Bioscience