PDE1B-HEK293 Cell line

Catalog number: 60402
Brand: BPS Bioscience
Packing: 2 Vials
Price: € 9621.00
Expected delivery time: 7 days

Product specifications for - PDE1B-HEK293 Cell line

Product group: Arrays / Slides
Category: Cell (line)
Application note: Useful to monitor cAMP and PDE1B signaling pathway activity and to screen activators or inhibitors of PDE1B.
Target: PDE1B
Target description: phosphodiesterase 1B
Datasheet: Datasheet
  Research Use Only
UNSPSC: 41122100
Form supplied: aqueous solution containing DMSO
Storage instructions: Liquid Nitrogen
Scientific information: 
Scientific info: Recombinant HEK293 cell line expressing human PDE1B (phosphodiesterase 1B, accession number NM_000924). N-terminal His-tagged human PDE1B has been stably expressed in HEK293 cell line and its expression was confirmed by Western blotting. The function of PDE1B was characterized by a cell-based cGMP assay. In this assay system, cells co-express atrial natriuretic peptide (ANP) receptor A (a guanylate cyclase), cyclic nucleotide5gated cation channel CNGA2, and the photoprotein aequorin. Intracellular cGMP level is monitored via aequorin luminescence induced by Ca2+ influx through CNGA2, acting as the intracellular cGMP sensor.
Gene ID: 5153
Swiss prot ID: Q01064
Additional information: 
Synonyms: 63 kDa Cam-PDE; calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; cam-PDE 1B; epididymis secretory sperm binding protein Li 79p; HEL-S-79p; PDE1B1; PDES1B; phosphodiesterase 1B, calmodulin-dependent; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B