1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

Catalog number: I882200_100mg
Brand: Toronto Research Chemicals
Packing: 100 mg
Other sizes: 10 mg
25 mg
500 mg
1 g
Price: On Request
Expected delivery time: 21 days
Quantity:

Product specifications for - 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 103745-39-7
Properties: 
Molecular Formula: C14H19Cl2N3O2S
Molecular weight: 364,28
Melting point: >238°C (dec.)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Form supplied: White to Off-White Solid
Storage instructions: -20-¦C Freezer
Scientific information: 
Scientific info: A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
Additional information: 
Synonyms: I882200; HA1077, Fasudil