1A-116 [1430208-73-3]

MedChem Express

1A-116 [1430208-73-3]

10

1430208-73-3

99.79%

C16H16F3N3

307.31

1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo.

N=C(NC1=CC=CC=C1C(F)(F)F)NC2=CC(C)=CC(C)=C2

2°C to 8°C,-20°C,-80°C

12352200