22-NHC . hydrochloride [360068-87-7, 3915-24-0]

Name: 22-NHC . hydrochloride [360068-87-7, 3915-24-0]
SKU: AG-CR1-3523_A27
Price: 68 EUR
Availability: InStock

AG-CR1-3523

Estimated Purity>98% (NMR)

Product group Chemicals

Molecular Weight387.6 . 36.5

Overview

Supplier
AdipoGen Life Sciences
Product Name
22-NHC . hydrochloride [360068-87-7, 3915-24-0]
Delivery Days Customer
10
Certification
Research Use Only
Estimated Purity
>98% (NMR)
Hazard Information
Non-hazardous,Warning
Molecular Formula
C26H45NO . HCl
Molecular Weight
387.6 . 36.5
Scientific Description
Aza-steroid [1]. Hedgehog signaling inhibitor [1]. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo) [1]. For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html . - Chemical. CAS: 360068-87-7 or 3915-24-0 (free base). Formula: C26H45NO . HCl. MW: 387.6 . 36.5. Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer) (Prod. No. AG-CR1-3524) http://www.adipogen.com/ag-cr1-3524/22-nhc-inactive-isomer.html .
SMILES
[Cl-].[H][C@@]12CC[C@H]([C@H](C)[NH2+]CCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9, 557 (2013)