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ProductsBack/6-Aminophenanthridine [832-68-8]
Chemical Structure
Chemical Structure
Chemical Structure

6-Aminophenanthridine [832-68-8]

Research Use Only
AG-MR-C0029
AdipoGen Life Sciences
Estimated Purity>97% (HPLC)
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Product group Chemicals
Molecular Weight194.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    6-Aminophenanthridine [832-68-8]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >97% (HPLC)
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C13H10N2
  • Molecular Weight
    194.2
  • Scientific Description
    Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation. - Chemical. CAS: 832-68-8. Formula: C13H10N2. MW: 194.2. Antiprion agent. Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.
  • SMILES
    NC1=NC2=C(C=CC=C2)C2=C1C=CC=C2
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005)
  • Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008)
  • Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008)
  • Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011)
  • Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011)
  • The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)