A 419259 (trihydrochloride) [1435934-25-0]

Catalog number: HY-15764A_10mg
Brand: MedChem Express
Packing: 10 mg
Other sizes: 5 mg
10 mM
50 mg
Price: € 219.60 € 244.00
Expected delivery time: 10 days

Product specifications for - A 419259 (trihydrochloride) [1435934-25-0]

Product group: Chemicals
Category: Inhibitors / activators
CAS No.: 1435934-25-0
Purity: >98%
Molecular Formula: C29H37Cl3N6O
Molecular weight: 592.0027
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: A 419259 3Hcl is an apoptosis inducing agent that inhibits Src family kinases (c-Src). A 419259 also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation. IC50 Value: 9 nM (Src), <3 nM (Lck), <3 nM (Lyn), 3 uM (Abl) [1] Target: Src family kinase in vitro: Treatment of the Ph+ CML cell lines K-562 and Meg-01 with A-419259 resulted in growth arrest and induction of apoptosis, while the Ph- leukemia cell lines TF-1 and HEL were unaffected over the same concentration ranges. Suppression of Ph+ cell growth by A-419259 correlated with a decrease in Src kinase autophosphorylation. A-419259 blocked Stat5 and Erk activation, consistent with the suppressive effects of the compounds on survival and proliferation [1]. A-419259 treatment blocks all Src-family kinase activity in ES cells, preventing differentiation while maintaining pluripotency. Expression of inhibitor-resistant c-Src but not c-Yes rescued the A-419259 differentiation block, resulting in a cell population with properties of both primitive ectoderm and endoderm [2]. Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased GRP-induced EGFR phosphorylation and MAPK activation in HNSCC [3].
Safety information: 
Additional information: 
Synonyms: HY-15764A; A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride