Abiraterone acetate [154229-18-2]

Catalog number: HY-75054_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: Also available in other sizes.
Price: € 127.00
Expected delivery time: 10 days

Product specifications for - Abiraterone acetate [154229-18-2]

Product group: Chemicals
Category: Other
CAS No.: 154229-18-2
Purity: >98%
Molecular Formula: C26H33NO2
Molecular weight: 391.55
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Abiraterone acetate (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM. Abiraterone is used in treatment of prostate cancer. IC50 value: Target: CYP17 Abiraterone, a potent suppressor of cytochrome P450 17 alpha-hydroxysteroid dehydrogenase-mediated androgen production, has heralded a new era in the hormonal treatment of men with metastatic CRPC. Abiraterone acetate is associated with hypokalaemia, hypertension, and fluid retention or oedema, secondary to its mechanism of action, and with cardiac adverse events and hepatotoxicity, however, in the phase III studies the incidences of the most frequently reported grade 3 or 4 adverse events of special interest were relatively low.
Safety information: 
Effects of gonadectomy and inhibition of of androgen synthesis on behavioural flexibility in male rats', Tomm, Ryan Justin. University of British Columbia. 2017-08-18. Read more
Intracrine androgen biosynthesis in renal cell carcinoma', Lee GT. Br J Cancer. 2017 Mar 28;116(7):937-943. Read more