ABT-737 [852808-04-9]
HY-50907
CAS Number852808-04-9
Product group Chemicals
Estimated Purity98.38%
Molecular Weight813.43
Overview
- SupplierMedChem Express
- Product NameABT-737 [852808-04-9]
- Delivery Days Customer10
- CAS Number852808-04-9
- CertificationResearch Use Only
- Estimated Purity98.38%
- Molecular FormulaC42H45ClN6O5S2
- Molecular Weight813.43
- Scientific DescriptionABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.
- SMILESCN(CC[C@@H](NC1=CC=C(C=C1[N+]([O-])=O)S(NC(C2=CC=C(C=C2)N3CCN(CC3)CC4=CC=CC=C4C5=CC=C(C=C5)Cl)=O)(=O)=O)CSC6=CC=CC=C6)C
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200