Acalabrutinib [1420477-60-6]

MedChem Express

Acalabrutinib [1420477-60-6]

10

1420477-60-6

Research Use Only

98%

C26H23N7O2

465.51

Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL).

O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2

2°C to 8°C,-20°C,-80°C

12352200